Cargando…

Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors

The vast majority of patients with acute myeloid leukemia (AML) achieve complete remission (CR) after standard induction chemotherapy. However, the majority subsequently relapse and die of the disease. A leukemia stem cell (LSC) paradigm has been invoked to explain this failure of CR to reliably tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Venton, G, Pérez-Alea, M, Baier, C, Fournet, G, Quash, G, Labiad, Y, Martin, G, Sanderson, F, Poullin, P, Suchon, P, Farnault, L, Nguyen, C, Brunet, C, Ceylan, I, Costello, R T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056970/ https://www.ncbi.nlm.nih.gov/pubmed/27611922 http://dx.doi.org/10.1038/bcj.2016.78

Ejemplares similares

Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer
por: Rebollido-Rios, Rocio, et al.
Publicado: (2020)

Sepsis and neutropenia in hematological malignancies
por: Labiad, Y, et al.
Publicado: (2014)

A red-shifted fluorescent substrate for aldehyde dehydrogenase
por: Minn, Il, et al.
Publicado: (2014)

The contribution of single-cell analysis of acute leukemia in the therapeutic strategy
por: Madaci, Lamia, et al.
Publicado: (2021)

Impact of Next-Generation Sequencing in Diagnosis, Prognosis and Therapeutic Management of Acute Myeloid Leukemia/Myelodysplastic Neoplasms
por: Madaci, Lamia, et al.
Publicado: (2023)

Alcohol dehydrogenase and aldehyde dehydrogenase in malignant neoplasms
por: Orywal, Karolina, et al.
Publicado: (2016)

Update on the aldehyde dehydrogenase gene (ALDH) superfamily
por: Jackson, Brian, et al.
Publicado: (2011)

Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency
por: Matsumura, Yuki, et al.
Publicado: (2019)

Mitochondrial aldehyde dehydrogenase and cardiac diseases
por: Chen, Che-Hong, et al.
Publicado: (2010)

SAXS fingerprints of aldehyde dehydrogenase oligomers
por: Tanner, John J.
Publicado: (2015)

Aldehyde Dehydrogenase, Liver Disease and Cancer
por: Wang, Wenjun, et al.
Publicado: (2020)

Aldehyde Dehydrogenase 1 in Gastric Cancer
por: Wang, Ling, et al.
Publicado: (2022)

Partially Irreversible Inactivation of Mitochondrial Aldehyde Dehydrogenase by Nitroglycerin
por: Beretta, Matteo, et al.
Publicado: (2008)

Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists
por: Kusuma, Gina D., et al.
Publicado: (2017)

Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
por: Farnault, Laure, et al.
Publicado: (2012)

The Genetics of Alcohol Metabolism: Role of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Variants
por: Edenberg, Howard J.
Publicado: (2007)

Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis
por: Yan, J, et al.
Publicado: (2014)

Bioactivation of pentaerythrityl tetranitrate by mitochondrial aldehyde dehydrogenase
por: Griesberger, Martina, et al.
Publicado: (2009)

The Expression of Aldehyde Dehydrogenase Family in Breast Cancer
por: Qiu, Yan, et al.
Publicado: (2014)

The Aldehyde Dehydrogenase Gene Superfamily Resource Center
por: Black, William, et al.
Publicado: (2009)

Targeting aldehyde dehydrogenase for prostate cancer therapies
por: Ma, Miao, et al.
Publicado: (2022)

ERYTHROCYTE ALDEHYDE DEHYDROGENASE = A POTENTIAL MARKER FOR ALCOHOL DEPENDENCE
por: Murthy, Pratitma, et al.
Publicado: (1996)

Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDHIAI*4
por: Moore, Shelley M, et al.
Publicado: (2009)

Activity of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in sera of patients with hepatitis C
por: Jelski, Wojciech, et al.
Publicado: (2016)

Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities
por: Srinivasan, Shraddha, et al.
Publicado: (2019)

Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus
por: Halavaty, Andrei S., et al.
Publicado: (2015)

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans
por: Arif, Sayqa, et al.
Publicado: (2015)

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology
por: Joshi, Amit U., et al.
Publicado: (2019)

Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases
por: Beretta, Matteo, et al.
Publicado: (2008)

The role of fatty aldehyde dehydrogenase in epidermal structure and function
por: Rizzo, William B
Publicado: (2011)

The roles of aldehyde dehydrogenases (ALDHs) in the PDH bypass of Arabidopsis
por: Wei, Yanling, et al.
Publicado: (2009)

Aldehyde dehydrogenase is used by cancer cells for energy metabolism
por: Kang, Joon Hee, et al.
Publicado: (2016)

Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective
por: Shortall, Kim, et al.
Publicado: (2021)

Association Study of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Alzheimer Disease in the Taiwanese Population
por: Wu, Yah-Yuan, et al.
Publicado: (2021)

Salivary Aldehyde Dehydrogenase: Activity towards Aromatic Aldehydes and Comparison with Recombinant ALDH3A1
por: Giebułtowicz, Joanna, et al.
Publicado: (2009)

Aberrant reactive aldehyde detoxification by aldehyde dehydrogenase-2 influences endometriosis development and pain-associated behaviors
por: McAllister, Stacy L., et al.
Publicado: (2021)

Natural Killer Cells Modulation in Hematological Malignancies
por: Baier, Céline, et al.
Publicado: (2013)

Can Gene Therapy Be Used to Prevent Cancer? Gene Therapy for Aldehyde Dehydrogenase 2 Deficiency
por: Montel, Rachel A., et al.
Publicado: (2022)

Aldehyde Dehydrogenase 3 Is an Expanded Gene Family with Potential Adaptive Roles in Chickpea
por: Carmona-Molero, Rocío, et al.
Publicado: (2021)

The Activity of Alcohol Dehydrogenase (ADH) Isoenzymes and Aldehyde Dehydrogenase (ALDH) in the Sera of Patients with Brain Cancer
por: Jelski, Wojciech, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_u9i9lal8ir1aqvoq3h4s34g8ii