Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments

No independent cross-validation of success rate for studies utilizing small interfering RNA (siRNA) for gene silencing has been completed before. To assess the influence of experimental parameters like cell line, transfection technique, validation method, and type of control, we have to validate the...

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Detalles Bibliográficos
Autores principales: Munkácsy, Gyöngyi, Sztupinszki, Zsófia, Herman, Péter, Bán, Bence, Pénzváltó, Zsófia, Szarvas, Nóra, Győrffy, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056990/
https://www.ncbi.nlm.nih.gov/pubmed/27673562
http://dx.doi.org/10.1038/mtna.2016.66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056990/
https://www.ncbi.nlm.nih.gov/pubmed/27673562
http://dx.doi.org/10.1038/mtna.2016.66

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