Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

Sclerostin is a protein secreted by osteocytes that is encoded by the SOST gene; it decreases bone formation by reducing osteoblast differentiation through inhibition of the Wnt signaling pathway. Silencing the SOST gene using RNA interference (RNAi) could therefore be an effective way to treat oste...

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Detalles Bibliográficos
Autores principales: Basha, Genc, Ordobadi, Mina, Scott, Wilder R, Cottle, Andrew, Liu, Yan, Wang, Haitang, Cullis, Pieter R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056992/
https://www.ncbi.nlm.nih.gov/pubmed/27623445
http://dx.doi.org/10.1038/mtna.2016.68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056992/
https://www.ncbi.nlm.nih.gov/pubmed/27623445
http://dx.doi.org/10.1038/mtna.2016.68

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