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Nuclear envelope rupture is induced by actin-based nucleus confinement

Repeated rounds of nuclear envelope (NE) rupture and repair have been observed in laminopathy and cancer cells and result in intermittent loss of nucleus compartmentalization. Currently, the causes of NE rupture are unclear. Here, we show that NE rupture in cancer cells relies on the assembly of con...

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Detalles Bibliográficos
Autores principales: Hatch, Emily M., Hetzer, Martin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057282/
https://www.ncbi.nlm.nih.gov/pubmed/27697922
http://dx.doi.org/10.1083/jcb.201603053