GEF-H1 is necessary for neutrophil shear stress–induced migration during inflammation

Leukocyte crawling and transendothelial migration (TEM) are potentiated by shear stress caused by blood flow. The mechanism that couples shear stress to migration has not been fully elucidated. We found that mice lacking GEF-H1 (GEF-H1(−/−)), a RhoA-specific guanine nucleotide exchange factor (GEF),...

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Detalles Bibliográficos
Autores principales: Fine, Noah, Dimitriou, Ioannis D., Rullo, Jacob, Sandí, María José, Petri, Björn, Haitsma, Jack, Ibrahim, Hisham, La Rose, Jose, Glogauer, Michael, Kubes, Paul, Cybulsky, Myron, Rottapel, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057286/
https://www.ncbi.nlm.nih.gov/pubmed/27738004
http://dx.doi.org/10.1083/jcb.201603109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057286/
https://www.ncbi.nlm.nih.gov/pubmed/27738004
http://dx.doi.org/10.1083/jcb.201603109

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