Neutrophil mechanotransduction: A GEF to sense fluid shear stress

Forces deriving from blood flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed tissues, but the mechanisms by which shear is sensed are unclear. In this issue, Fine et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603109) identify the guanosi...

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Detalles Bibliográficos
Autor principal: Niethammer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057290/
https://www.ncbi.nlm.nih.gov/pubmed/27738002
http://dx.doi.org/10.1083/jcb.201609101
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author Niethammer, Philipp
author_facet Niethammer, Philipp
author_sort Niethammer, Philipp
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description Forces deriving from blood flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed tissues, but the mechanisms by which shear is sensed are unclear. In this issue, Fine et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603109) identify the guanosine nucleotide exchange factor GEF-H1 as critical for shear stress–induced transendothelial neutrophil migration.
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spelling pubmed-50572902017-04-10 Neutrophil mechanotransduction: A GEF to sense fluid shear stress Niethammer, Philipp J Cell Biol Commentary Forces deriving from blood flow shear modulate vascular adherence and transendothelial migration of leukocytes into inflamed tissues, but the mechanisms by which shear is sensed are unclear. In this issue, Fine et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603109) identify the guanosine nucleotide exchange factor GEF-H1 as critical for shear stress–induced transendothelial neutrophil migration. The Rockefeller University Press 2016-10-10 /pmc/articles/PMC5057290/ /pubmed/27738002 http://dx.doi.org/10.1083/jcb.201609101 Text en © 2016 Niethammer This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Niethammer, Philipp
Neutrophil mechanotransduction: A GEF to sense fluid shear stress
title Neutrophil mechanotransduction: A GEF to sense fluid shear stress
title_full Neutrophil mechanotransduction: A GEF to sense fluid shear stress
title_fullStr Neutrophil mechanotransduction: A GEF to sense fluid shear stress
title_full_unstemmed Neutrophil mechanotransduction: A GEF to sense fluid shear stress
title_short Neutrophil mechanotransduction: A GEF to sense fluid shear stress
title_sort neutrophil mechanotransduction: a gef to sense fluid shear stress
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057290/
https://www.ncbi.nlm.nih.gov/pubmed/27738002
http://dx.doi.org/10.1083/jcb.201609101
work_keys_str_mv AT niethammerphilipp neutrophilmechanotransductionageftosensefluidshearstress

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