Comparing domain interactions within antibody Fabs with kappa and lambda light chains

IgG antibodies are multi-domain proteins with complex inter-domain interactions. Human IgG heavy chains (HCs) associate with light chains (LCs) of the κ or λ isotype to form mature antibodies capable of binding antigen. The HC/LC interaction involves 4 domains: VH and CH1 from the HC and VL and CL f...

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Detalles Bibliográficos
Autores principales: Toughiri, Raheleh, Wu, Xiufeng, Ruiz, Diana, Huang, Flora, Crissman, John W., Dickey, Mark, Froning, Karen, Conner, Elaine M., Cujec, Thomas P., Demarest, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058631/
https://www.ncbi.nlm.nih.gov/pubmed/27454112
http://dx.doi.org/10.1080/19420862.2016.1214785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058631/
https://www.ncbi.nlm.nih.gov/pubmed/27454112
http://dx.doi.org/10.1080/19420862.2016.1214785

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