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Comparing domain interactions within antibody Fabs with kappa and lambda light chains

IgG antibodies are multi-domain proteins with complex inter-domain interactions. Human IgG heavy chains (HCs) associate with light chains (LCs) of the κ or λ isotype to form mature antibodies capable of binding antigen. The HC/LC interaction involves 4 domains: VH and CH1 from the HC and VL and CL f...

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Detalles Bibliográficos
Autores principales:	Toughiri, Raheleh, Wu, Xiufeng, Ruiz, Diana, Huang, Flora, Crissman, John W., Dickey, Mark, Froning, Karen, Conner, Elaine M., Cujec, Thomas P., Demarest, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058631/ https://www.ncbi.nlm.nih.gov/pubmed/27454112 http://dx.doi.org/10.1080/19420862.2016.1214785

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