Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

Recombinant immunotoxins (RITs) are genetically engineered proteins being developed to treat cancer. They are composed of an Fv that targets a cancer antigen and a portion of a protein toxin. Their clinical success is limited by their immunogenicity. Our goal is to produce a new RIT that targets mes...

Descripción completa

Detalles Bibliográficos
Autores principales: Mazor, Ronit, Onda, Masanori, Park, Dong, Addissie, Selamawit, Xiang, Laiman, Zhang, Jingli, Hassan, Raffit, Pastan, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058652/
https://www.ncbi.nlm.nih.gov/pubmed/27167198
http://dx.doi.org/10.18632/oncotarget.9171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058652/
https://www.ncbi.nlm.nih.gov/pubmed/27167198
http://dx.doi.org/10.18632/oncotarget.9171

Ejemplares similares