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Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity

Recombinant immunotoxins (RITs) are genetically engineered proteins being developed to treat cancer. They are composed of an Fv that targets a cancer antigen and a portion of a protein toxin. Their clinical success is limited by their immunogenicity. Our goal is to produce a new RIT that targets mes...

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Detalles Bibliográficos
Autores principales:	Mazor, Ronit, Onda, Masanori, Park, Dong, Addissie, Selamawit, Xiang, Laiman, Zhang, Jingli, Hassan, Raffit, Pastan, Ira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058652/ https://www.ncbi.nlm.nih.gov/pubmed/27167198 http://dx.doi.org/10.18632/oncotarget.9171

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