Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice

The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1(−/−)) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR signalling induces such effects is unclear,...

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Detalles Bibliográficos
Autores principales: Selman, Colin, Sinclair, Amy, Pedroni, Silvia M.A., Irvine, Elaine E., Michie, Alison M., Withers, Dominic J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058654/
https://www.ncbi.nlm.nih.gov/pubmed/27083004
http://dx.doi.org/10.18632/oncotarget.8729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058654/
https://www.ncbi.nlm.nih.gov/pubmed/27083004
http://dx.doi.org/10.18632/oncotarget.8729

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