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Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice
The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1(−/−)) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR signalling induces such effects is unclear,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058654/ https://www.ncbi.nlm.nih.gov/pubmed/27083004 http://dx.doi.org/10.18632/oncotarget.8729 |