Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway

Proteomic analysis of ionomycin-treated and untreated mammary epithelial MCF10A cells elucidated differences in Ku80 cleavage. Ku80, a subunit of the Ku protein complex, is an initiator of the non-homologous, end-joining (NHEJ), double-strand breaks (DSBs) repair pathway. The nuclear Ku80 was cleave...

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Detalles Bibliográficos
Autores principales: Baek, Kyung Hye, Yu, Han Vit, Kim, Eosu, Na, Younghwa, Kwon, Youngjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058721/
https://www.ncbi.nlm.nih.gov/pubmed/27121057
http://dx.doi.org/10.18632/oncotarget.8791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058721/
https://www.ncbi.nlm.nih.gov/pubmed/27121057
http://dx.doi.org/10.18632/oncotarget.8791

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