Asclepiasterol, a novel C21 steroidal glycoside derived from Asclepias curassavica, reverses tumor multidrug resistance by down-regulating P-glycoprotein expression

Multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) is a major cause of cancer therapy failure. In this study, we identified a novel C(21) steroidal glycoside, asclepiasterol, capable of reversing P-gp-mediated MDR. Asclepiasterol (2.5 and 5.0μM) enhanced the cytotoxity of P-gp substrate an...

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Detalles Bibliográficos
Autores principales: Yuan, Wei-Qi, Zhang, Rong-Rong, Wang, Jun, Ma, Yan, Li, Wen-Xue, Jiang, Ren-Wang, Cai, Shao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058771/
https://www.ncbi.nlm.nih.gov/pubmed/27129170
http://dx.doi.org/10.18632/oncotarget.8965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058771/
https://www.ncbi.nlm.nih.gov/pubmed/27129170
http://dx.doi.org/10.18632/oncotarget.8965

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