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Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency

When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon trauma. Yet, little is known regarding the mechanistic basis controlling initial and homeostatic ‘scaling’ of stem cell pool sizes relative to their target tissues for effective regeneration. Here, we show th...

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Detalles Bibliográficos
Autores principales: Southard, Sheryl, Kim, Ju-Ryoung, Low, SiewHui, Tsika, Richard W, Lepper, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059137/
https://www.ncbi.nlm.nih.gov/pubmed/27725085
http://dx.doi.org/10.7554/eLife.15461