Evaluation of the characteristics of leucyl-tRNA synthetase (LeuRS) inhibitor AN3365 in combination with different antibiotic classes

Aminoacyl tRNA synthetases are enzymes involved in the key process of coupling an amino acid to its cognate tRNA. AN3365 is a novel antibiotic that specifically targets leucyl-tRNA synthetase, whose development was halted after evaluation in phase II clinical trials owing to the rapid selection of r...

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Detalles Bibliográficos
Autores principales: Monteferrante, C. G., Jirgensons, A., Varik, V., Hauryliuk, V., Goessens, W. H. F., Hays, J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059401/
https://www.ncbi.nlm.nih.gov/pubmed/27506217
http://dx.doi.org/10.1007/s10096-016-2738-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059401/
https://www.ncbi.nlm.nih.gov/pubmed/27506217
http://dx.doi.org/10.1007/s10096-016-2738-1

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