Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

DNA double-strand breaks (DSBs) leading to loss of nucleotides in the transcribed region can be lethal. Classical non-homologous end-joining (C-NHEJ) is the dominant pathway for DSB repair (DSBR) in adult mammalian cells. Here we report that during such DSBR, mammalian C-NHEJ proteins form a multipr...

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Detalles Bibliográficos
Autores principales: Chakraborty, Anirban, Tapryal, Nisha, Venkova, Tatiana, Horikoshi, Nobuo, Pandita, Raj K., Sarker, Altaf H., Sarkar, Partha S., Pandita, Tej K., Hazra, Tapas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059474/
https://www.ncbi.nlm.nih.gov/pubmed/27703167
http://dx.doi.org/10.1038/ncomms13049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059474/
https://www.ncbi.nlm.nih.gov/pubmed/27703167
http://dx.doi.org/10.1038/ncomms13049

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