Cargando…

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

DNA double-strand breaks (DSBs) leading to loss of nucleotides in the transcribed region can be lethal. Classical non-homologous end-joining (C-NHEJ) is the dominant pathway for DSB repair (DSBR) in adult mammalian cells. Here we report that during such DSBR, mammalian C-NHEJ proteins form a multipr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chakraborty, Anirban, Tapryal, Nisha, Venkova, Tatiana, Horikoshi, Nobuo, Pandita, Raj K., Sarker, Altaf H., Sarkar, Partha S., Pandita, Tej K., Hazra, Tapas K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059474/ https://www.ncbi.nlm.nih.gov/pubmed/27703167 http://dx.doi.org/10.1038/ncomms13049

Ejemplares similares

Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks
por: Chakraborty, Anirban, et al.
Publicado: (2023)

Chromatin remodeling finds its place in the DNA double-strand break response
por: Pandita, Tej K., et al.
Publicado: (2009)

SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair
por: Chakraborty, Sharmistha, et al.
Publicado: (2018)

Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks
por: Chakraborty, Sharmistha, et al.
Publicado: (2022)

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
por: Bolderson, Emma, et al.
Publicado: (2010)

β2-spectrin depletion impairs DNA damage repair
por: Horikoshi, Nobuo, et al.
Publicado: (2016)

E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability
por: Fukuyo, Yayoi, et al.
Publicado: (2011)

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase
por: Horikoshi, Nobuo, et al.
Publicado: (2019)

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
por: Chatterjee, Arpita, et al.
Publicado: (2015)

Role of Histone Methylation in Maintenance of Genome Integrity
por: Mushtaq, Arjamand, et al.
Publicado: (2021)

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks
por: Bolderson, Emma, et al.
Publicado: (2014)

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
por: Helmink, Beth A., et al.
Publicado: (2009)

Chromatin modifications and the DNA damage response to ionizing radiation
por: Kumar, Rakesh, et al.
Publicado: (2013)

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
por: Hussain, Tabish, et al.
Publicado: (2017)

Cellular Senescence as a Brake or Accelerator for Oncogenic Transformation and Role in Lymphatic Metastasis
por: Banerjee, Priyanka, et al.
Publicado: (2023)

Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression
por: Horikoshi, Nobuo, et al.
Publicado: (2013)

Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection
por: Pan, Lang, et al.
Publicado: (2023)

Site-specific acetylation of polynucleotide kinase 3’-phosphatase (PNKP) regulates its distinct role in DNA repair pathways
por: Islam, Azharul, et al.
Publicado: (2023)

Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin
por: Manova, Vasilissa, et al.
Publicado: (2012)

Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination
por: Mujoo, Kalpana, et al.
Publicado: (2017)

To Join or Not to Join: Decision Points Along the Pathway to Double-Strand Break Repair vs. Chromosome End Protection
por: Ackerson, Stephanie M., et al.
Publicado: (2021)

Functional analysis of a conserved site mutation in the DNA end processing enzyme PNKP leading to ataxia with oculomotor apraxia type 4 in humans
por: Islam, Azharul, et al.
Publicado: (2023)

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
por: Di Virgilio, Michela, et al.
Publicado: (2005)

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining
por: Keka, Islam Shamima, et al.
Publicado: (2015)

Intrapulmonary administration of purified NEIL2 abrogates NF-κB–mediated inflammation
por: Tapryal, Nisha, et al.
Publicado: (2021)

NRF2 Regulates Cystathionine Gamma-Lyase Expression and Activity in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus
por: Jamaluddin, Mohammad, et al.
Publicado: (2022)

Emerging therapeutic targets in esophageal adenocarcinoma
por: Gaur, Puja, et al.
Publicado: (2016)

Nuclear functions of β2-Spectrin in genomic stability
por: Mujoo, Kalpana, et al.
Publicado: (2016)

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
por: Couto, C. Anne-Marie, et al.
Publicado: (2011)

Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks
por: Girst, S., et al.
Publicado: (2013)

ZEB1 promotes non-homologous end joining double-strand break repair
por: Genetta, Thomas L, et al.
Publicado: (2023)

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks
por: Mansour, Wael Y., et al.
Publicado: (2008)

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions
por: Tadi, Satish Kumar, et al.
Publicado: (2016)

In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density
por: Henthorn, N. T., et al.
Publicado: (2018)

Erratum: miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
por: Patel, Nibedita, et al.
Publicado: (2017)

miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
por: Patel, Nibedita, et al.
Publicado: (2017)

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Essential Factors for Incompatible DNA End Joining at Chromosomal DNA Double Strand Breaks In Vivo
por: Ogiwara, Hideaki, et al.
Publicado: (2011)

Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms
por: Kostyrko, Kaja, et al.
Publicado: (2016)

Plant organellar DNA polymerases repair double-stranded breaks by microhomology-mediated end-joining
por: García-Medel, Paola L, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tjjkpblmfv4hko2efi9dbj87e9