Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice

Aim. Models combining diabetes and atherosclerosis are important in evaluating the cardiovascular (CV) effects and safety of antidiabetes drugs in the development of treatments targeting CV complications. Our aim was to evaluate if crossing the heterozygous glucokinase knockout mouse (GK(+/−)) and h...

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Detalles Bibliográficos
Autores principales: Adingupu, Damilola D., Heinonen, Suvi E., Andréasson, Anne-Christine, Brusberg, Mikael, Ahnmark, Andrea, Behrendt, Margareta, Leighton, Brendan, Jönsson-Rylander, Ann-Cathrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059602/
https://www.ncbi.nlm.nih.gov/pubmed/27774459
http://dx.doi.org/10.1155/2016/8630961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059602/
https://www.ncbi.nlm.nih.gov/pubmed/27774459
http://dx.doi.org/10.1155/2016/8630961

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