A long-acting GH receptor antagonist through fusion to GH binding protein

Acromegaly is a human disease of growth hormone (GH) excess with considerable morbidity and increased mortality. Somatostatin analogues are first line medical treatment but the disease remains uncontrolled in up to 40% of patients. GH receptor (GHR) antagonist therapy is more effective but requires...

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Detalles Bibliográficos
Autores principales: Wilkinson, Ian R., Pradhananga, Sarbendra L., Speak, Rowena, Artymiuk, Peter J., Sayers, Jon R., Ross, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059632/
https://www.ncbi.nlm.nih.gov/pubmed/27731358
http://dx.doi.org/10.1038/srep35072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059632/
https://www.ncbi.nlm.nih.gov/pubmed/27731358
http://dx.doi.org/10.1038/srep35072

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