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Tetrameric structure of the restriction DNA glycosylase R.PabI in complex with nonspecific double-stranded DNA

R.PabI is a type II restriction enzyme that recognizes the 5′-GTAC-3′ sequence and belongs to the HALFPIPE superfamily. Although most restriction enzymes cleave phosphodiester bonds at specific sites by hydrolysis, R.PabI flips the guanine and adenine bases of the recognition sequence out of the DNA...

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Detalles Bibliográficos
Autores principales: Wang, Delong, Miyazono, Ken-ichi, Tanokura, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059719/
https://www.ncbi.nlm.nih.gov/pubmed/27731370
http://dx.doi.org/10.1038/srep35197