TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells

Excessive production of reactive oxygen species (ROS) induced by hyperglycemia increased the secretion of interleukin-1β (IL-1β), which contributes to the pathogenesis of diabetes and its complications. Although high glucose (HG)-induced oxidative stress and aberrant Ca(2+) channels activity causes...

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Detalles Bibliográficos
Autores principales: Tseng, Hisa Hui Ling, Vong, Chi Teng, Kwan, Yiu Wa, Lee, Simon Ming-Yuen, Hoi, Maggie Pui Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059733/
https://www.ncbi.nlm.nih.gov/pubmed/27731349
http://dx.doi.org/10.1038/srep35016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059733/
https://www.ncbi.nlm.nih.gov/pubmed/27731349
http://dx.doi.org/10.1038/srep35016

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