Cargando…

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

The TOR and Insulin/IGF signalling (IIS) network controls growth, metabolism and ageing. Although reducing TOR or insulin signalling can be beneficial for ageing, it can be detrimental for wound healing, but the reasons for this difference are unknown. Here we show that IIS is activated in the cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kakanj, Parisa, Moussian, Bernard, Grönke, Sebastian, Bustos, Victor, Eming, Sabine A., Partridge, Linda, Leptin, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059774/ https://www.ncbi.nlm.nih.gov/pubmed/27713427 http://dx.doi.org/10.1038/ncomms12972

Ejemplares similares

Autophagy–mediated plasma membrane removal promotes the formation of epithelial syncytia
por: Kakanj, Parisa, et al.
Publicado: (2022)

Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities
por: Bukowiecki, Anne, et al.
Publicado: (2017)

Foxo1 Inhibits Diabetic Mucosal Wound Healing but Enhances Healing of Normoglycemic Wounds
por: Xu, Fanxing, et al.
Publicado: (2015)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

FOXO1, TGF-β Regulation and Wound Healing
por: Hameedaldeen, Alhassan, et al.
Publicado: (2014)

Adult zebrafish as a model system for cutaneous wound healing research
por: Richardson, Rebecca, et al.
Publicado: (2013)

The adherens junction–associated LIM domain protein Smallish regulates epithelial morphogenesis
por: Beati, Hamze, et al.
Publicado: (2018)

dFOXO-independent effects of reduced insulin-like signaling in Drosophila
por: Slack, Cathy, et al.
Publicado: (2011)

A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States
por: Slaidina, Maija, et al.
Publicado: (2009)

FOXO1 differentially regulates both normal and diabetic wound healing
por: Zhang, Chenying, et al.
Publicado: (2015)

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides
por: Grönke, Sebastian, et al.
Publicado: (2010)

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
por: Partridge, Linda, et al.
Publicado: (2011)

Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila
por: Metaxakis, Athanasios, et al.
Publicado: (2014)

Insulin signalling regulates remating in female Drosophila
por: Wigby, Stuart, et al.
Publicado: (2011)

FoxO3a depletion accelerates cutaneous wound healing by regulating epithelial-mesenchymal transition through β-catenin activation
por: Liu, Ting, et al.
Publicado: (2020)

Forces driving epithelial wound healing
por: Brugués, Agustí, et al.
Publicado: (2014)

Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier Formation
por: Wang, Juan, et al.
Publicado: (2022)

Parallels between vertebrate cardiac and cutaneous wound healing and regeneration
por: Richardson, Rebecca J.
Publicado: (2018)

Reduced insulin signaling in neurons induces sex-specific health benefits
por: Baghdadi, Maarouf, et al.
Publicado: (2023)

Longevity in response to lowered insulin signaling requires glycine N‐methyltransferase‐dependent spermidine production
por: Tain, Luke S., et al.
Publicado: (2019)

FOXO1 deletion in keratinocytes improves diabetic wound healing through MMP9 regulation
por: Zhang, Chenying, et al.
Publicado: (2017)

Thrombomodulin Promotes Corneal Epithelial Wound Healing
por: Huang, Yi-Hsun, et al.
Publicado: (2015)

The Epithelial Sodium Channel and the Processes of Wound Healing
por: Chifflet, Silvia, et al.
Publicado: (2016)

Dioleoylphosphatidylglycerol Accelerates Corneal Epithelial Wound Healing
por: Bollag, Wendy B., et al.
Publicado: (2020)

Tissue Fluidity Promotes Epithelial Wound Healing
por: Tetley, Robert J., et al.
Publicado: (2019)

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
por: Alic, Nazif, et al.
Publicado: (2011)

Branched-Chain Amino Acids Have Equivalent Effects to Other Essential Amino Acids on Lifespan and Aging-Related Traits in Drosophila
por: Juricic, Paula, et al.
Publicado: (2020)

An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila
por: Weigelt, Carina Marianne, et al.
Publicado: (2020)

Insulin Topical Application for Wound Healing in Nondiabetic Patients
por: Sun, Shudong, et al.
Publicado: (2021)

Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing
por: Macedo, Ana S., et al.
Publicado: (2021)

Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models
por: Squarize, Cristiane H., et al.
Publicado: (2010)

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
por: Li, Yi, et al.
Publicado: (2021)

JBP485 promotes corneal epithelial wound healing
por: Nagata, Maho, et al.
Publicado: (2015)

FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress
por: Ponugoti, Bhaskar, et al.
Publicado: (2013)

Transcription Factor Binding Site Analysis Identifies FOXO Transcription Factors as Regulators of the Cutaneous Wound Healing Process
por: Roupé, Karl Markus, et al.
Publicado: (2014)

Sugar saps FOXO1’s healing power
por: Leslie, Mitch
Publicado: (2015)

Correction to: mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
por: Li, Yi, et al.
Publicado: (2021)

Effect of Bacteria on the Wound Healing Behavior of Oral Epithelial Cells
por: Bhattacharya, Rupa, et al.
Publicado: (2014)

Re-epithelialization: advancing epithelium frontier during wound healing
por: Ben Amar, M., et al.
Publicado: (2014)

Review: Corneal epithelial stem cells, their niche and wound healing
por: Castro-Muñozledo, Federico
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_lrulo6do8ukmi72hccjfrtnn7t