Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

CD47 signaling in endothelial cells has been shown to suppress angiogenesis, but little is known about the link between CD47 and endothelial senescence. Herein, we demonstrate that the thrombospondin-1 (TSP1)-CD47 signaling pathway is a major mechanism for driving endothelial cell senescence. CD47 d...

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Detalles Bibliográficos
Autores principales: Gao, Qi, Chen, Kexin, Gao, Lu, Zheng, Yang, Yang, Yong-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059850/
https://www.ncbi.nlm.nih.gov/pubmed/27607583
http://dx.doi.org/10.1038/cddis.2016.155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059850/
https://www.ncbi.nlm.nih.gov/pubmed/27607583
http://dx.doi.org/10.1038/cddis.2016.155

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