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Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells
CD47 signaling in endothelial cells has been shown to suppress angiogenesis, but little is known about the link between CD47 and endothelial senescence. Herein, we demonstrate that the thrombospondin-1 (TSP1)-CD47 signaling pathway is a major mechanism for driving endothelial cell senescence. CD47 d...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059850/ https://www.ncbi.nlm.nih.gov/pubmed/27607583 http://dx.doi.org/10.1038/cddis.2016.155 |