Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice

Inhibition of the apoptosis pathway controlled by opposing members of the Bcl-2 protein family plays a central role in cancer development and resistance to therapy. To investigate how pro-apoptotic Bcl-2 homology domain 3 (BH3)-only proteins impact on acute myeloid leukemia (AML), we generated mixed...

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Detalles Bibliográficos
Autores principales: Bilardi, Rebecca A, Anstee, Natasha S, Glaser, Stefan P, Robati, Mikara, Vandenberg, Cassandra J, Cory, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059861/
https://www.ncbi.nlm.nih.gov/pubmed/27584789
http://dx.doi.org/10.1038/cddis.2016.258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059861/
https://www.ncbi.nlm.nih.gov/pubmed/27584789
http://dx.doi.org/10.1038/cddis.2016.258

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