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Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival and regeneration-promoting factor for dopaminergic neurons in cell and animal models of Parkinson disease (PD). GDNF is currently tested in clinical trials on PD patients with so far inconclusive results. The receptor tyrosine k...

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Detalles Bibliográficos
Autores principales: Drinkut, Anja, Tillack, Karsten, Meka, Durga P, Schulz, Jorg B, Kügler, Sebastian, Kramer, Edgar R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059866/
https://www.ncbi.nlm.nih.gov/pubmed/27607574
http://dx.doi.org/10.1038/cddis.2016.263