Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

Acute myeloid leukemia (AML) is a hierarchical hematopoietic malignancy originating from leukemic stem cells (LSCs). Autophagy is a lysosomal degradation pathway that is hypothesized to be important for the maintenance of AML as well as contribute to chemotherapy response. Here we employ a mouse mod...

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Detalles Bibliográficos
Autores principales: Liu, Qiang, Chen, Longgui, Atkinson, Jennifer M, Claxton, David F, Wang, Hong-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059867/
https://www.ncbi.nlm.nih.gov/pubmed/27607576
http://dx.doi.org/10.1038/cddis.2016.264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059867/
https://www.ncbi.nlm.nih.gov/pubmed/27607576
http://dx.doi.org/10.1038/cddis.2016.264

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