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CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling
Mechanisms of DNA damage and repair signaling are not completely understood that hinder the efficiency of cancer therapy. Urokinase-type plasminogen activator receptor (PLAUR) is highly expressed in most solid cancers and serves as a marker of poor prognosis. We show that PLAUR actively promotes DNA...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059885/ https://www.ncbi.nlm.nih.gov/pubmed/27685627 http://dx.doi.org/10.1038/cddis.2016.291 |