Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation

The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake of both endogenous substrates and xenobiotics....

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Detalles Bibliográficos
Autores principales: Pinne, Marija, Ponce, Elsa, Raucy, Judy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061317/
https://www.ncbi.nlm.nih.gov/pubmed/27732639
http://dx.doi.org/10.1371/journal.pone.0164642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061317/
https://www.ncbi.nlm.nih.gov/pubmed/27732639
http://dx.doi.org/10.1371/journal.pone.0164642

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