Cargando…
Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake of both endogenous substrates and xenobiotics....
Autores principales: | Pinne, Marija, Ponce, Elsa, Raucy, Judy L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061317/ https://www.ncbi.nlm.nih.gov/pubmed/27732639 http://dx.doi.org/10.1371/journal.pone.0164642 |
Ejemplares similares
-
Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice
por: Shizu, Ryota, et al.
Publicado: (2013) -
Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor
por: Mathäs, Marianne, et al.
Publicado: (2014) -
Signaling control of the constitutive androstane receptor (CAR)
por: Yang, Hui, et al.
Publicado: (2014) -
Constitutive androstane receptor 1 is constitutively bound to
chromatin and ‘primed’ for transactivation in hepatocytes
por: McMahon, Michael, et al.
Publicado: (2019) -
Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor
Publicado: (2014)