Exploring the scope of new arylamino alcohol derivatives: Synthesis, antimalarial evaluation, toxicological studies, and target exploration

Synthesis of new 1-aryl-3-substituted propanol derivatives followed by structure-activity relationship, in silico drug-likeness, cytotoxicity, genotoxicity, in silico metabolism, in silico pharmacophore modeling, and in vivo studies led to the identification of compounds 22 and 23 with significant i...

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Detalles Bibliográficos
Autores principales: Quiliano, Miguel, Mendoza, Adela, Fong, Kim Y., Pabón, Adriana, Goldfarb, Nathan E., Fabing, Isabelle, Vettorazzi, Ariane, López de Cerain, Adela, Dunn, Ben M., Garavito, Giovanny, Wright, David W., Deharo, Eric, Pérez-Silanes, Silvia, Aldana, Ignacio, Galiano, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061469/
https://www.ncbi.nlm.nih.gov/pubmed/27718413
http://dx.doi.org/10.1016/j.ijpddr.2016.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061469/
https://www.ncbi.nlm.nih.gov/pubmed/27718413
http://dx.doi.org/10.1016/j.ijpddr.2016.09.004

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