TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here, we show that the elephant genome...

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Detalles Bibliográficos
Autores principales: Sulak, Michael, Fong, Lindsey, Mika, Katelyn, Chigurupati, Sravanthi, Yon, Lisa, Mongan, Nigel P, Emes, Richard D, Lynch, Vincent J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061548/
https://www.ncbi.nlm.nih.gov/pubmed/27642012
http://dx.doi.org/10.7554/eLife.11994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061548/
https://www.ncbi.nlm.nih.gov/pubmed/27642012
http://dx.doi.org/10.7554/eLife.11994

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