p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma

BACKGROUND: PERP (p53 apoptosis effector related to PMP-22), a transcriptional target of p53, is downregulated and contributes to the impairment of apoptosis in uveal melanoma (UM). Intriguingly, PERP is not induced in UM despite functional p53. p63, located on chromosome 3, which is characteristica...

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Detalles Bibliográficos
Autores principales: Awais, Raheela, Spiller, David G, White, Michael R H, Paraoan, Luminita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061904/
https://www.ncbi.nlm.nih.gov/pubmed/27584665
http://dx.doi.org/10.1038/bjc.2016.269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061904/
https://www.ncbi.nlm.nih.gov/pubmed/27584665
http://dx.doi.org/10.1038/bjc.2016.269

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