MPTP Impairs Dopamine D1 Receptor-Mediated Survival of Newborn Neurons in Ventral Hippocampus to Cause Depressive-Like Behaviors in Adult Mice

Parkinson’s disease (PD) is characterized by motor symptoms with depression. We evaluated the influence of dopaminergic depletion on hippocampal neurogenesis process to explore mechanisms of depression production. Five consecutive days of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection...

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Detalles Bibliográficos
Autores principales: Zhang, Tingting, Hong, Juan, Di, Tingting, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062058/
https://www.ncbi.nlm.nih.gov/pubmed/27790091
http://dx.doi.org/10.3389/fnmol.2016.00101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062058/
https://www.ncbi.nlm.nih.gov/pubmed/27790091
http://dx.doi.org/10.3389/fnmol.2016.00101

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