Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking

Cyclotides or cyclic cystine-knot peptides have emerged as a promising class of pharmacological ligands that modulate protein function. Interestingly, very few cyclotides have been shown to enter into cells. Yet, it remains unknown whether backbone cyclization is required for their cellular internal...

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Detalles Bibliográficos
Autores principales: Gao, Xinxin, Stanger, Karen, Kaluarachchi, Harini, Maurer, Till, Ciepla, Paulina, Chalouni, Cecile, Franke, Yvonne, Hannoush, Rami N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062073/
https://www.ncbi.nlm.nih.gov/pubmed/27734922
http://dx.doi.org/10.1038/srep35179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062073/
https://www.ncbi.nlm.nih.gov/pubmed/27734922
http://dx.doi.org/10.1038/srep35179

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