Development of a one-pot assay for screening and identification of Mur pathway inhibitors in Mycobacterium tuberculosis

The cell wall of Mycobacterium tuberculosis (Mtb) consists of peptidoglycan, arabinogalactan and mycolic acids. The cytoplasmic steps in the peptidoglycan biosynthetic pathway, catalyzed by the Mur (A-F) enzymes, involve the synthesis of UDP-n-acetylmuramyl pentapeptide, a key precursor molecule req...

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Detalles Bibliográficos
Autores principales: Eniyan, Kandasamy, Kumar, Anuradha, Rayasam, Geetha Vani, Perdih, Andrej, Bajpai, Urmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062083/
https://www.ncbi.nlm.nih.gov/pubmed/27734910
http://dx.doi.org/10.1038/srep35134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062083/
https://www.ncbi.nlm.nih.gov/pubmed/27734910
http://dx.doi.org/10.1038/srep35134

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