High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1

Pembrolizumab is an FDA-approved therapeutic antibody that targets the programmed cell death-1 (PD-1) to block the immune checkpoint pathway for the treatment of various types of cancer. It receives remarkable attention due to the high degree of efficacy. Very recently, the crystal structure of the...

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Detalles Bibliográficos
Autores principales: Horita, Shoichiro, Nomura, Yayoi, Sato, Yumi, Shimamura, Tatsuro, Iwata, So, Nomura, Norimichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062252/
https://www.ncbi.nlm.nih.gov/pubmed/27734966
http://dx.doi.org/10.1038/srep35297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062252/
https://www.ncbi.nlm.nih.gov/pubmed/27734966
http://dx.doi.org/10.1038/srep35297

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