Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life

Membrane proteins are crucial in transport, signaling, bioenergetics, catalysis, and as drug targets. Here, we show that membrane proteins have dramatically fewer detectable orthologs than water-soluble proteins, less than half in most species analyzed. This sparse distribution could reflect rapid d...

Descripción completa

Detalles Bibliográficos
Autores principales: Sojo, Victor, Dessimoz, Christophe, Pomiankowski, Andrew, Lane, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062322/
https://www.ncbi.nlm.nih.gov/pubmed/27501943
http://dx.doi.org/10.1093/molbev/msw164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062322/
https://www.ncbi.nlm.nih.gov/pubmed/27501943
http://dx.doi.org/10.1093/molbev/msw164

Ejemplares similares