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Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life
Membrane proteins are crucial in transport, signaling, bioenergetics, catalysis, and as drug targets. Here, we show that membrane proteins have dramatically fewer detectable orthologs than water-soluble proteins, less than half in most species analyzed. This sparse distribution could reflect rapid d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062322/ https://www.ncbi.nlm.nih.gov/pubmed/27501943 http://dx.doi.org/10.1093/molbev/msw164 |