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Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
Circadian rhythms controlled by clock genes affect plasma lipids. Here we show that global ablation of Bmal1 in Apoe(−/−) and Ldlr(−/−) mice and its liver-specific ablation in Apoe(−/−) (L-Bmal1(−/−)Apoe(−/−)) mice increases, whereas overexpression of BMAL1 in L-Bmal1(−/−)Apoe(−/−) and Apoe(−/−)mice...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062545/ https://www.ncbi.nlm.nih.gov/pubmed/27721414 http://dx.doi.org/10.1038/ncomms13011 |