ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling and oxidative stress have been implicated in the pathogenesis of the ALS-FTLD spectrum of neurodegenerative disorders. The Keap1-binding partn...

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Detalles Bibliográficos
Autores principales: Goode, Alice, Rea, Sarah, Sultana, Melanie, Shaw, Barry, Searle, Mark S., Layfield, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062946/
https://www.ncbi.nlm.nih.gov/pubmed/27554286
http://dx.doi.org/10.1016/j.mcn.2016.08.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062946/
https://www.ncbi.nlm.nih.gov/pubmed/27554286
http://dx.doi.org/10.1016/j.mcn.2016.08.004

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