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ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
The transcription factor Nrf2 and its repressor protein Keap1 play key roles in the regulation of antioxidant stress responses and both Keap1-Nrf2 signalling and oxidative stress have been implicated in the pathogenesis of the ALS-FTLD spectrum of neurodegenerative disorders. The Keap1-binding partn...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062946/ https://www.ncbi.nlm.nih.gov/pubmed/27554286 http://dx.doi.org/10.1016/j.mcn.2016.08.004 |