Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme

Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome-targeting antibiotics. The same adenosine is als...

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Detalles Bibliográficos
Autores principales: Stojković, Vanja, Noda-Garcia, Lianet, Tawfik, Dan S., Fujimori, Danica Galonić
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062987/
https://www.ncbi.nlm.nih.gov/pubmed/27496281
http://dx.doi.org/10.1093/nar/gkw699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062987/
https://www.ncbi.nlm.nih.gov/pubmed/27496281
http://dx.doi.org/10.1093/nar/gkw699

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