Cargando…

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme

Modifications of the bacterial ribosome regulate the function of the ribosome and modulate its susceptibility to antibiotics. By modifying a highly conserved adenosine A2503 in 23S rRNA, methylating enzyme Cfr confers resistance to a range of ribosome-targeting antibiotics. The same adenosine is als...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stojković, Vanja, Noda-Garcia, Lianet, Tawfik, Dan S., Fujimori, Danica Galonić
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062987/ https://www.ncbi.nlm.nih.gov/pubmed/27496281 http://dx.doi.org/10.1093/nar/gkw699

Ejemplares similares

Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site
por: Mak, Amanda Nga-Sze, et al.
Publicado: (2007)

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
por: Tsai, Kaitlyn, et al.
Publicado: (2022)

DNA cleavage and methylation specificity of the single polypeptide restriction–modification enzyme LlaGI
por: Smith, Rachel M., et al.
Publicado: (2009)

Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4
por: Walter, Justin D., et al.
Publicado: (2012)

Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage
por: Rockah-Shmuel, Liat, et al.
Publicado: (2012)

Recognition of the 70S ribosome and polysome by the RNA degradosome in Escherichia coli
por: Tsai, Yi-Chun, et al.
Publicado: (2012)

Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis
por: Surovtseva, Yulia V., et al.
Publicado: (2013)

Archaeal aminoacyl-tRNA synthetases interact with the ribosome to recycle tRNAs
por: Godinic-Mikulcic, Vlatka, et al.
Publicado: (2014)

A ribosome profiling study of mRNA cleavage by the endonuclease RelE
por: Hwang, Jae-Yeon, et al.
Publicado: (2017)

Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center
por: Willi, Jessica, et al.
Publicado: (2018)

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA
por: Kudrin, Pavel, et al.
Publicado: (2018)

The critical function of the plastid rRNA methyltransferase, CMAL, in ribosome biogenesis and plant development
por: Zou, Meijuan, et al.
Publicado: (2020)

Activation of RegB endoribonuclease by S1 ribosomal protein requires an 11 nt conserved sequence
por: Durand, Sylvain, et al.
Publicado: (2006)

Characterization of Aquifex aeolicus ribonuclease III and the reactivity epitopes of its pre-ribosomal RNA substrates
por: Shi, Zhongjie, et al.
Publicado: (2011)

Molecular basis of ribosome recognition and mRNA hydrolysis by the E. coli YafQ toxin
por: Maehigashi, Tatsuya, et al.
Publicado: (2015)

The human methyltransferase ZCCHC4 catalyses N(6)-methyladenosine modification of 28S ribosomal RNA
por: Pinto, Rita, et al.
Publicado: (2020)

Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth
por: Heissenberger, Clemens, et al.
Publicado: (2019)

YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria
por: D’Souza, Aaron R, et al.
Publicado: (2021)

Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP
por: Demeshkina, Natalia, et al.
Publicado: (2007)

Nucleobase modification by an RNA enzyme
por: Poudyal, Raghav R., et al.
Publicado: (2017)

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
por: Espada, Jesús, et al.
Publicado: (2007)

Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans
por: Meyer, Britta, et al.
Publicado: (2016)

Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression
por: Fox, Kate L., et al.
Publicado: (2007)

The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases
por: Leulliot, Nicolas, et al.
Publicado: (2008)

The ribosome assembly factor Nep1 responsible for Bowen–Conradi syndrome is a pseudouridine-N1-specific methyltransferase
por: Wurm, Jan Philip, et al.
Publicado: (2010)

A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit
por: Sharpe Elles, Lisa M., et al.
Publicado: (2009)

RNase AM, a 5′ to 3′ exonuclease, matures the 5′ end of all three ribosomal RNAs in E. coli
por: Jain, Chaitanya
Publicado: (2020)

Spring loading a pre-cleavage intermediate for hairpin telomere formation
por: Lucyshyn, Danica, et al.
Publicado: (2015)

C-terminal lysine repeats in Streptomyces topoisomerase I stabilize the enzyme–DNA complex and confer high enzyme processivity
por: Strzałka, Agnieszka, et al.
Publicado: (2017)

The K(+)-dependent GTPase Nug1 is implicated in the association of the helicase Dbp10 to the immature peptidyl transferase centre during ribosome maturation
por: Manikas, Rizos-Georgios, et al.
Publicado: (2016)

The DEAH-box RNA helicase Dhr1 contains a remarkable carboxyl terminal domain essential for small ribosomal subunit biogenesis
por: Roychowdhury, Amlan, et al.
Publicado: (2019)

Atomic force microscopy of the EcoKI Type I DNA restriction enzyme bound to DNA shows enzyme dimerization and DNA looping
por: Neaves, Kelly J., et al.
Publicado: (2009)

Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages
por: Olorunniji, Femi J., et al.
Publicado: (2015)

Sinorhizobium meliloti YbeY is a zinc-dependent single-strand specific endoribonuclease that plays an important role in 16S ribosomal RNA processing
por: Babu, Vignesh M P, et al.
Publicado: (2020)

Type I restriction endonucleases are true catalytic enzymes
por: Bianco, Piero R., et al.
Publicado: (2009)

Complementation of aprataxin deficiency by base excision repair enzymes
por: Çağlayan, Melike, et al.
Publicado: (2015)

Target site cleavage by the monomeric restriction enzyme BcnI requires translocation to a random DNA sequence and a switch in enzyme orientation
por: Sasnauskas, Giedrius, et al.
Publicado: (2011)

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
por: Li, Ya-Qiang, et al.
Publicado: (2007)

Single-site DNA cleavage by Type III restriction endonuclease requires a site-bound enzyme and a trans-acting enzyme that are ATPase-activated
por: Ahmad, Ishtiyaq, et al.
Publicado: (2018)

Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm
por: Sato, Shigeko, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1p61566u5e9escqe924ut98m9b