Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1

Transcription factors have been considered undruggable, but this paradigm has been recently challenged. DNA binding natural product mithramycin (MTM) is a potent antagonist of oncogenic transcription factor EWS–FLI1. Structural details of MTM recognition of DNA, including the FLI1 binding sequence G...

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Detalles Bibliográficos
Autores principales: Hou, Caixia, Weidenbach, Stevi, Cano, Kristin E., Wang, Zhonghua, Mitra, Prithiba, Ivanov, Dmitri N., Rohr, Jürgen, Tsodikov, Oleg V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063001/
https://www.ncbi.nlm.nih.gov/pubmed/27587584
http://dx.doi.org/10.1093/nar/gkw761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063001/
https://www.ncbi.nlm.nih.gov/pubmed/27587584
http://dx.doi.org/10.1093/nar/gkw761

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