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Pharmacokinetics of serelaxin in patients with severe renal impairment or end‐stage renal disease requiring hemodialysis: A single‐dose, open‐label, parallel‐group study

Serelaxin, a recombinant human relaxin‐2 hormone, is in clinical development for treating acute heart failure. This open‐label, parallel‐group study investigated serelaxin pharmacokinetics (PK) after a single 4‐hour intravenous infusion (10 µg/kg) in patients with severe renal impairment (n = 6) or...

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Detalles Bibliográficos
Autores principales: Dahlke, Marion, Halabi, Atef, Canadi, Jasna, Tsubouchi, Chiaki, Machineni, Surendra, Pang, Yinuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063144/
https://www.ncbi.nlm.nih.gov/pubmed/26239266
http://dx.doi.org/10.1002/jcph.607