IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle

HIV-1 post-integration latency in CD4+ lymphocytes is responsible for viral persistence despite treatment, but mechanisms involved in the establishment of latent viral reservoirs are not fully understood. We determined that both interleukin 2 (IL-2) and IL-7 induced SAMHD1 phosphorylation in T592, a...

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Detalles Bibliográficos
Autores principales: Coiras, Mayte, Bermejo, Mercedes, Descours, Benjamin, Mateos, Elena, García-Pérez, Javier, López-Huertas, María-Rosa, Lederman, Michael M., Benkirane, Monsef, Alcamí, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063304/
https://www.ncbi.nlm.nih.gov/pubmed/26923586
http://dx.doi.org/10.1016/j.celrep.2016.02.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063304/
https://www.ncbi.nlm.nih.gov/pubmed/26923586
http://dx.doi.org/10.1016/j.celrep.2016.02.022

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