Cargando…

IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle

HIV-1 post-integration latency in CD4+ lymphocytes is responsible for viral persistence despite treatment, but mechanisms involved in the establishment of latent viral reservoirs are not fully understood. We determined that both interleukin 2 (IL-2) and IL-7 induced SAMHD1 phosphorylation in T592, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coiras, Mayte, Bermejo, Mercedes, Descours, Benjamin, Mateos, Elena, García-Pérez, Javier, López-Huertas, María-Rosa, Lederman, Michael M., Benkirane, Monsef, Alcamí, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063304/ https://www.ncbi.nlm.nih.gov/pubmed/26923586 http://dx.doi.org/10.1016/j.celrep.2016.02.022

Ejemplares similares

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
por: Descours, Benjamin, et al.
Publicado: (2012)

Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IκBα and enhances HIV-1 replication in human T lymphocytes
por: Coiras, Mayte, et al.
Publicado: (2008)

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity
por: Wittmann, Sabine, et al.
Publicado: (2015)

Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression
por: Coiras, Mayte, et al.
Publicado: (2007)

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2012)

Molecular mechanisms involved in HIV latency and implications for HIV treatment and eradication
por: Alcami, Jose, et al.
Publicado: (2010)

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity
por: De Meo, Simone, et al.
Publicado: (2020)

Transcriptomic Evidence of the Immune Response Activation in Individuals With Limb Girdle Muscular Dystrophy Dominant 2 (LGMDD2) Contributes to Resistance to HIV-1 Infection
por: Diez-Fuertes, Francisco, et al.
Publicado: (2022)

SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts
por: Wichit, Sineewanlaya, et al.
Publicado: (2019)

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection
por: Rodríguez-Mora, Sara, et al.
Publicado: (2019)

Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells
por: Sánchez-Del Cojo, María, et al.
Publicado: (2017)

PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells
por: López-Huertas, María Rosa, et al.
Publicado: (2016)

Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication
por: Coiras, Mayte, et al.
Publicado: (2013)

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
por: Herrmann, Alexandra, et al.
Publicado: (2018)

Modifications in host cell structure and functions mediated by Tat intracellular expression are greatly dependent on the second exon
por: López-Huertas, María Rosa, et al.
Publicado: (2009)

Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon
por: López-Huertas, M. R., et al.
Publicado: (2010)

The CCR5-antagonist Maraviroc reverses HIV-1 latency in vitro alone or in combination with the PKC-agonist Bryostatin-1
por: López-Huertas, María Rosa, et al.
Publicado: (2017)

Correction to: The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
por: Herrmann, A., et al.
Publicado: (2018)

SAMHD1 Phosphorylation at T592 Regulates Cellular Localization and S-phase Progression
por: Batalis, Stephanie, et al.
Publicado: (2021)

Back to the cell cycle with SAMHD1 and its viral antagonist, Vpx
por: Margottin-Goguet, Florence
Publicado: (2013)

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle
por: Sommer, Andreas F. R., et al.
Publicado: (2016)

Regulation of HIV-1 gene expression
por: Benkirane, Monsef
Publicado: (2013)

Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing
por: Montes, Marta, et al.
Publicado: (2015)

Substrates and Inhibitors of SAMHD1
por: Hollenbaugh, Joseph A., et al.
Publicado: (2017)

Intracellular expression of Tat alters mitochondrial functions in T cells: a potential mechanism to understand mitochondrial damage during HIV-1 replication
por: Rodríguez-Mora, Sara, et al.
Publicado: (2015)

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
por: Tsai, Ming-Han C., et al.
Publicado: (2023)

SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition
por: Szaniawski, Matthew A., et al.
Publicado: (2018)

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
por: Miyakawa, Kei, et al.
Publicado: (2019)

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
por: Martinat, Charlotte, et al.
Publicado: (2021)

Restriction of diverse retroviruses by SAMHD1
por: Gramberg, Thomas, et al.
Publicado: (2013)

SAMHD1 Functions and Human Diseases
por: Coggins, Si’Ana A., et al.
Publicado: (2020)

SAMHD1 … and Viral Ways around It
por: Deutschmann, Janina, et al.
Publicado: (2021)

SAMHD1 in cancer: curse or cure?
por: Schott, Kerstin, et al.
Publicado: (2021)

Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection
por: Fu, Weihui, et al.
Publicado: (2016)

The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592
por: Tramentozzi, Elisa, et al.
Publicado: (2018)

Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway
por: Ren, Huiling, et al.
Publicado: (2020)

Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1
por: Brandariz-Nuñez, Alberto, et al.
Publicado: (2013)

Mechanism of Allosteric Activation of SAMHD1 by dGTP
por: Ji, Xiaoyun, et al.
Publicado: (2013)

Molecular mechanisms of the interplay between Vpx and SAMHD1
por: Wu, Ying, et al.
Publicado: (2013)

SAMHD1-dependent retroviral control and escape in mice
por: Rehwinkel, Jan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ps9cn2rovpkvuuon8p4blgumo2