Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ

Nilotinib and imatinib are tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). In vitro, imatinib and nilotinib inhibit osteoclastogenesis, and in patients they reduce levels of bone resorption. One of the mechanisms t...

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Detalles Bibliográficos
Autores principales: O’Sullivan, Susannah, Tay, Mei Lin, Lin, Jian-Ming, Bava, Usha, Callon, Karen, Cornish, Jillian, Naot, Dorit, Grey, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063333/
https://www.ncbi.nlm.nih.gov/pubmed/27737004
http://dx.doi.org/10.1371/journal.pone.0164727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063333/
https://www.ncbi.nlm.nih.gov/pubmed/27737004
http://dx.doi.org/10.1371/journal.pone.0164727

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